Basics Spyre Therapeutics, Inc. IPO Date: April 4, 2016 Sector: Healthcare Industry: Biotech Market Cap: $1.03B Activated in VL: True Average Daily Range Avg Daily Range: $0.84 | 3.40% Avg Daily Range (30 D): $0.39 | 2.33% Avg Daily Range (90 D): $0.41 | 2.58% Institutional Daily Volume Avg Daily Volume: .42M Avg Daily Volume (30 D): .36M Avg Daily Volume (90 D): .36M Trade Size Avg Trade Size (Sh.): 63 Avg Trade Size (Sh.) (30 D): 55 Avg Trade Size (Sh.) (90 D): 55 Institutional Trades Total Inst.Trades: 802 Avg Inst. Trade: $2.01M Avg Inst. Trade (30 D): $1.59M Avg Inst. Trade (90 D): $1.78M Avg Inst. Trade Volume: .08M Avg Inst. Trades (Per Day): 2 Market Closing Trades Avg Closing Trade: $2.47M Avg Closing Trade (30 D): $1.58M Avg Closing Trade (90 D): $1.96M Avg Closing Volume: 109.96K     News Aug 1, 2025 @ 8:41 PM Spyre Therapeutics Announces Grants of Inducement ... Source: Eric Mcintyre Mar 5, 2024 @ 3:56 PM NIO Reports Upbeat Earnings, Joins Dave, V2X, Risk... Source: Avi Kapoor Mar 4, 2024 @ 1:50 PM Here's What Could Help Spyre Therapeutics (SYRE) M... Source: Zacks Equity Research Feb 6, 2024 @ 2:55 PM Here's Why Spyre Therapeutics (SYRE) Could be Grea... Source: Zacks Equity Research Financials   TTM Q1 2025 Q3 2024 Basic EPS $-1.36 Diluted EPS $-1.36 Revenue $ M $ M $ M Gross Profit $ $ $ Net Income / Loss $ -36.72M $ -44.77M $ -69.03M Operating Income / Loss $ -41.94M $ -53.57M $ -55.39M Cost of Revenue $ $ $ Net Cash Flow $ 33.17M $ -40.93M $ 26.12M PE Ratio     Splits Sep 08, 2023:   1:25