Basics Spyre Therapeutics, Inc. IPO Date: April 4, 2016 Sector: Healthcare Industry: Biotech Market Cap: $2.6B Activated in VL: True Average Daily Range Avg Daily Range: $0.82 | 3.41% Avg Daily Range (30 D): $0.82 | 3.21% Avg Daily Range (90 D): $0.63 | 3.13% Institutional Daily Volume Avg Daily Volume: .45M Avg Daily Volume (30 D): .56M Avg Daily Volume (90 D): .6M Trade Size Avg Trade Size (Sh.): 62 Avg Trade Size (Sh.) (30 D): 52 Avg Trade Size (Sh.) (90 D): 58 Institutional Trades Total Inst.Trades: 945 Avg Inst. Trade: $2M Avg Inst. Trade (30 D): $1.98M Avg Inst. Trade (90 D): $1.87M Avg Inst. Trade Volume: .08M Avg Inst. Trades (Per Day): 2 Market Closing Trades Avg Closing Trade: $2.56M Avg Closing Trade (30 D): $2.75M Avg Closing Trade (90 D): $2.58M Avg Closing Volume: 114.63K     News Oct 24, 2025 @ 12:00 PM Spyre Therapeutics Announces Poster Presentations ... Source: Spyre Therapeutics Oct 14, 2025 @ 1:07 AM Spyre Therapeutics Announces Pricing of $275.0 Mil... Source: Spyre Therapeutics Oct 5, 2025 @ 1:00 PM Spyre Therapeutics Announces Poster Presentations ... Source: Spyre Therapeutics Aug 1, 2025 @ 8:41 PM Spyre Therapeutics Announces Grants of Inducement ... Source: Eric Mcintyre Mar 5, 2024 @ 3:56 PM NIO Reports Upbeat Earnings, Joins Dave, V2X, Risk... Source: Avi Kapoor Financials   TTM Q2 2025 Q1 2025 Basic EPS Diluted EPS $-.15 Revenue $ M $ M $ M Gross Profit $ $ $ Net Income / Loss $ -11.18M $ -36.72M $ -44.77M Operating Income / Loss $ -56.89M $ -41.94M $ -53.57M Cost of Revenue $ $ $ Net Cash Flow $ -16.76M $ 33.17M $ -40.93M PE Ratio     Splits Sep 08, 2023:   1:25