Basics Upstream Bio, Inc. Common Stock IPO Date: October 11, 2024 Sector: Healthcare Industry: Biotech Market Cap: $1.5B Activated in VL: True Average Daily Range Avg Daily Range: $0.59 | 3.90% Avg Daily Range (30 D): $0.92 | 3.66% Avg Daily Range (90 D): $0.74 | 3.63% Institutional Daily Volume Avg Daily Volume: .31M Avg Daily Volume (30 D): .36M Avg Daily Volume (90 D): .39M Trade Size Avg Trade Size (Sh.): 64 Avg Trade Size (Sh.) (30 D): 59 Avg Trade Size (Sh.) (90 D): 62 Institutional Trades Total Inst.Trades: 230 Avg Inst. Trade: $1.56M Avg Inst. Trade (30 D): $1.31M Avg Inst. Trade (90 D): $1.23M Avg Inst. Trade Volume: .09M Avg Inst. Trades (Per Day): 1 Market Closing Trades Avg Closing Trade: $1.8M Avg Closing Trade (30 D): $1.18M Avg Closing Trade (90 D): $1.26M Avg Closing Volume: 108.72K     News Oct 31, 2025 @ 11:00 AM Upstream Bio to Participate in Upcoming November I... Source: Meggan Buckwell Jun 15, 2025 @ 11:45 AM Translational Data Illustrate a Mechanism of Great... Source: Upstream Bio, Inc. Jun 5, 2025 @ 11:00 AM Upstream Bio to Present Mechanistic Insights into ... Source: N/A Financials   TTM Q2 2025 Q1 2025 Basic EPS $-.63 $-.74 $-.51 Diluted EPS $-.63 $-.74 $-.51 Revenue $ .68M $ .94M $ .57M Gross Profit $ $ $ Net Income / Loss $ -33.75M $ -39.97M $ -27.27M Operating Income / Loss $ -37.83M $ -44.35M $ -32.01M Cost of Revenue $ $ $ Net Cash Flow $ 26.71M $ -25.85M $ -254.58M PE Ratio